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PEC Original Annotations
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Essentiality
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Class
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non-essential
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References (PMID)
|
Mol Microbiol. 1996;20(3):621-32.
Analysis of nitrate regulatory protein NarL-binding sites in the fdnG and narG operon control regions of Escherichia coli K-12.
Darwin AJ, Li J, Stewart V.
(
8736541
)
|
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Deletion
|
OCR67
(D)
,
OCR67-2
(D)
,
OCR67-5
(D)
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|
Related gene (W3110 PEC)
|
|
Gene Search
|
Search MG1655 PEC by gene name:
narL
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Related strains
|
|
Strains Search
|
Search strains by gene name:
narL
Search strains by all related name:
narL b1221 ECK1215 frdR JW1212 narR
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General information (Go to Linear View: )
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Gene Name
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narL
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Alternative name
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b1221,ECK1215,frdR,JW1212,narR
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|
Location, Length
|
1,274,402 - 1,275,052
(
-
)
;
27.47
min
;
651
(bp) ,
216
(aa)
|
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Product
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DNA-binding response regulator in two-component regulatory system with NarX (or NarQ)
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Operon Name
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narXL
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Note
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pleiotrophic regulation of anaerobic respiration: response regulator for nar, frd, dms and tor genes; GO_component: GO:0005737 - cytoplasm; GO_function: GO:0016563 - transcription activator activity; GO_function: GO:0016564 - transcription repressor activity; GO_process: GO:0009061 - anaerobic respiration; GO_process: GO:0006350 - transcription
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Function
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regulator; Energy metabolism, carbon: Anaerobic respiration
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Gene Ontology
|
GO:0000156
;
two-component response regulator activity ( narL )
GO:0000160
;
two-component signal transduction system (phosphorelay) ( narL )
GO:0000166
;
nucleotide binding ( narL )
GO:0003677
;
DNA binding ( narL )
GO:0003700
;
transcription factor activity ( narL )
GO:0005515
;
protein binding ( narL )
GO:0005524
;
ATP binding ( narL )
GO:0005622
;
intracellular ( narL )
GO:0006350
;
transcription ( narL )
GO:0006355
;
regulation of transcription, DNA-dependent ( narL )
GO:0042128
;
nitrate assimilation ( narL )
GO:0043565
;
sequence-specific DNA binding ( narL )
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PID
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1787473
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EC number
(KEGG Pathway)
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|
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SWISS-PROT
(
Show details
[
1
more]
)
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Entry name(Acc.no)
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NARX_ECOLI
(
P10956
)
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- Protein name
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Nitrate/nitrite sensor protein narX
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- Synonyms
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EC 2.7.3.-
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- Gene name
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OrderedLocusNames=b1222, z1998, ECs1727, SF1225, S1309;
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MMBR References
|
J Bacteriol. 1991;173(14):4424-32.
Mutational analysis of nitrate regulatory gene narL in Escherichia coli K-12.
Egan SM, Stewart V.
(
2066339
)
|
Nucleic Acids Res. 1989;17:1965-1975
Nucleotide sequence of the narL gene that is involved in global regulation of nitrate controlled respiratory genes of Escherichia coli.
Gunsalus, R. P., L. V. Kalman, and R. R. Stewart.
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Proc Natl Acad Sci U S A. 1987;84:3901-3905
The narL gene product activates the nitrate reductase operon and represses the fumarate reductase and trimethylamine N-oxide reductase operons in Escherichia coli.
Iuchi, S., and E. C. C. Lin.
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J Bacteriol. 1988;170(2):623-9.
The frdR gene of Escherichia coli globally regulates several operons involved in anaerobic growth in response to nitrate.
Kalman LV, Gunsalus RP.
(
3276662
)
|
J Bacteriol. 1989;171(7):3810-6.
Identification of a second gene involved in global regulation of fumarate reductase and other nitrate-controlled genes for anaerobic respiration in Escherichia coli.
Kalman LV, Gunsalus RP.
(
2544557
)
|
J Bacteriol. 1991;173(5):1574-5.
Locations of genes in the nar-adhE region of the Escherichia coli K-12 chromosome.
Leonardo MR, Clark DP.
(
1999382
)
|
Mol Gen Genet. 1981;181(1):95-100.
Molecular cloning of the fnr gene of Escherichia coli K12.
Shaw DJ, Guest JR.
(
6261088
)
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J Bacteriol. 1989;171(4):2229-34.
Structure of genes narL and narX of the nar (nitrate reductase) locus in Escherichia coli K-12.
Stewart V, Parales J Jr, Merkel SM.
(
2649492
)
|
J Bacteriol. 1988;170(4):1589-97.
Identification and expression of genes narL and narX of the nar (nitrate reductase) locus in Escherichia coli K-12.
Stewart V, Parales J Jr.
(
2832370
)
|
| Sequences |
Amino acid
FASTA format
|
0001 MSNQEPATIL LIDDHPMLRT GVKQLISMAP DITVVGEASN GEQGIELAES LDPDLILLDL NMPGMNGLET
0071 LDKLREKSLS GRIVVFSVSN HEEDVVTALK RGADGYLLKD MEPEDLLKAL HQAAAGEMVL SEALTPVLAA
0141 SLRANRATTE RDVNQLTPRE RDILKLIAQG LPNKMIARRL DITESTVKVH VKHMLKKMKL KSRVEAAVWV
0211 HQERIF
|
Nucleotide
FASTA format
View sequence out neighbor 100bp
|
-100 cgaggcgatt gccgcgtccg ccgtcgtgaa
-070 tcaggtggca ccgaagtggt ggtcaccttt attcccgaaa aaactttcac agacgtccaa ggagataccc
0001 atgagtaatc aggaaccggc tactatcctg ctgattgacg atcacccgat gctgcgaact ggcgtaaaac
0071 agcttatcag tatggcacca gatatcaccg tggttggcga agcgagtaat ggcgaacagg gtattgaact
0141 ggcggagtct cttgatcccg atctgatcct gttagatctc aatatgcccg gcatgaacgg tctggaaacg
0211 ctggataaac tgcgcgaaaa gtccctctca gggcgcattg tggtattcag cgtctctaac catgaagaag
0281 atgtggtcac cgcactgaaa cgcggcgcgg atggctatct gttaaaagat atggaaccgg aagatctgct
0351 gaaagcattg catcaggcag ctgctggcga aatggtatta agcgaagcat taacgcctgt tctggccgcc
0421 agcttgcgcg ctaaccgtgc cactactgag cgcgatgtta accagttaac cccacgcgag cgcgatattc
0491 tcaagctgat tgcccagggt ttgccgaaca agatgattgc ccgccgcctg gatatcaccg aaagcacagt
0561 aaaagtgcac gtcaagcaca tgctgaagaa aatgaagctc aagtctcgcg tggaagcagc ggtatgggtg
0631 catcaggagc gcattttctg attacggttc ccagcgcagt tcgtcgtttg acaatgcatc gaacggttcg
0701 acaagcgtta gcgtgatctc attggaggag acacgctgcc cctggttatc t
|
