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PEC Original Annotations
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Essentiality
|
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Class
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non-essential
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|
References (PMID)
|
|
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Deletion
|
DE(PLK1608)
,
OCL90-3
(D)
|
|
Related gene (W3110 PEC)
|
|
Gene Search
|
Search MG1655 PEC by gene name:
hdhA
|
|
Related strains
|
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Strains Search
|
Search strains by gene name:
hdhA
Search strains by all related name:
hdhA b1619 ECK1614 hsd hsdH JW1611
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General information (Go to Linear View: )
|
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Gene Name
|
hdhA
|
|
Alternative name
|
b1619,ECK1614,hsd,hsdH,JW1611
|
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Location, Length
|
1,695,297 - 1,696,064
(
-
)
;
36.54
min
;
768
(bp) ,
255
(aa)
|
|
Product
|
7-alpha-hydroxysteroid dehydrogenase, NAD-dependent
|
|
Operon Name
|
hdhA
|
|
Note
|
NAD-dependent 7alpha-hydroxysteroid dehydrogenase, dehydroxylation of bile acids; GO_component: GO:0005737 - cytoplasm
|
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Function
|
enzyme; Central intermediary metabolism: Pool, multipurpose conversions
|
|
Gene Ontology
|
GO:0003824
;
catalytic activity ( hdhA )
GO:0005488
;
binding ( hdhA )
GO:0006629
;
lipid metabolic process ( hdhA )
GO:0008152
;
metabolic process ( hdhA )
GO:0008202
;
steroid metabolic process ( hdhA )
GO:0008709
;
7-alpha-hydroxysteroid dehydrogenase activity ( hdhA )
GO:0016491
;
oxidoreductase activity ( hdhA )
GO:0030573
;
bile acid catabolic process ( hdhA )
|
|
PID
|
1787905
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EC number
(KEGG Pathway)
|
1.1.1.159
|
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Verified Protein Starts
(data
compiled from literature and appropriate citations are available from EcoGene)
|
|
EcoGene
|
hdhA
(
EG10425
)
|
|
Number of removed
|
0 aa cleaved
|
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SWISS-PROT
(
Show details
[
1
more]
)
|
Entry name(Acc.no)
|
HDHA_ECOLI
(
P25529
)
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|
- Protein name
|
7-alpha-hydroxysteroid dehydrogenase
|
|
- Synonyms
|
EC 1.1.1.159, 7-alpha-HSDH
|
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- Gene name
|
Name=hdhA; Synonyms=hsdH; OrderedLocusNames=b1619, z2624, ECs2327;
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MMBR References
|
J Bacteriol. 1993;175(17):5730
Location of the 7 alpha-hydroxysteroid dehydrogenase gene (hdhA) on the physical map of the Escherichia coli chromosome.
Yoshimoto T, Nagai H, Ito K, Tsuru D.
(
8366061
)
|
| Sequences |
Amino acid
FASTA format
|
0001 MFNSDNLRLD GKCAIITGAG AGIGKEIAIT FATAGASVVV SDINADAANH VVDEIQQLGG QAFACRCDIT
0071 SEQELSALAD FAISKLGKVD ILVNNAGGGG PKPFDMPMAD FRRAYELNVF SFFHLSQLVA PEMEKNGGGV
0141 ILTITSMAAE NKNINMTSYA SSKAAASHLV RNMAFDLGEK NIRVNGIAPG AILTDALKSV ITPEIEQKML
0211 QHTPIRRLGQ PQDIANAALF LCSPAASWVS GQILTVSGGG VQELN
|
Nucleotide
FASTA format
View sequence out neighbor 100bp
|
-100 tctgctatac ctggtagtgt cctttcctca
-070 aggttaatga taaaaaatgt ggcacacagg cggtgccttt tatttttact gaagttcaca ggaggtttat
0001 gtgtttaatt ctgacaacct gagactcgac ggaaaatgcg ccatcatcac aggtgcgggt gcaggtattg
0071 gtaaagaaat cgccattaca ttcgcgacag ctggcgcatc tgtggtggtc agtgatatta acgccgacgc
0141 agctaaccat gttgtagacg aaattcaaca actgggtggt caggcatttg cctgccgttg tgatattact
0211 tccgaacagg aactctctgc actggcagac tttgctatca gtaagctggg taaagttgat attctggtta
0281 acaacgccgg tggcggtgga cctaaaccgt ttgatatgcc aatggcggat tttcgccgtg cttatgaact
0351 gaatgtgttt tcttttttcc atctgtcaca acttgttgcg ccagaaatgg aaaaaaatgg cggtggcgtt
0421 attctgacca tcacttctat ggcggcagaa aataaaaata taaacatgac ttcctatgca tcatctaaag
0491 ctgcggccag tcatctggtc agaaatatgg cgtttgacct gggtgaaaaa aatattcggg taaatggcat
0561 tgcgccgggg gcaatattaa ccgatgccct gaaatccgtt attacaccag aaattgaaca aaaaatgtta
0631 cagcacacgc cgatcagacg tctgggccaa ccgcaagata ttgctaacgc agcgctgttc ctttgctcgc
0701 ctgctgcgag ctgggtaagc ggacaaattc tcaccgtctc cggtggtggg gtacaggagc tcaattaata
0771 cactaacgga ccggtaaaca accgtgcgtg ttgtttaccg ggataaactc atcaacgtct ctgctaaata
0841 actggcagcc aaatcacggc tattggtt
|
