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PEC Original Annotations
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|
Essentiality
|
|
Class
|
non-essential
|
|
References (PMID)
|
J Bacteriol. 1988;170(3):1069-75.
Lethality of a dut (deoxyuridine triphosphatase) mutation in Escherichia coli.
el-Hajj HH, Zhang H, Weiss B.
(
2830228
)
|
|
|
Deletion
|
DE(sbcB-rfb)202
,
16-2
(ND)
(LD)
,
OCL74-1
(D)
,
OCL74-4 (LD 16-2_CRS)
(D)
,
OCL74-5 (LD 16-2_P/O)
(D)
|
|
Related gene (W3110 PEC)
|
|
Gene Search
|
Search MG1655 PEC by gene name:
cdd
|
|
Related strains
|
|
Strains Search
|
Search strains by gene name:
cdd
Search strains by all related name:
cdd b2143 ECK2136 JW2131
|
General information (Go to Linear View: )
|
|
Gene Name
|
cdd
|
|
Alternative name
|
b2143,ECK2136,JW2131
|
|
Location, Length
|
2,229,866 - 2,230,750
(
+
)
;
48.06
min
;
885
(bp) ,
294
(aa)
|
|
Product
|
cytidine/deoxycytidine deaminase
|
|
Operon Name
|
cdd
|
|
Note
|
GO_process: GO:0015949 - nucleobase, nucleoside and nucleotide interconversion
|
|
Function
|
enzyme; Salvage of nucleosides and nucleotides
|
|
Gene Ontology
|
GO:0003824
;
catalytic activity ( cdd )
GO:0004126
;
cytidine deaminase activity ( cdd )
GO:0008270
;
zinc ion binding ( cdd )
GO:0016787
;
hydrolase activity ( cdd )
GO:0046087
;
cytidine metabolic process ( cdd )
GO:0046872
;
metal ion binding ( cdd )
|
|
PID
|
1788465
|
EC number
(KEGG Pathway)
|
3.5.4.5
|
|
Verified Protein Starts
(data
compiled from literature and appropriate citations are available from EcoGene)
|
|
EcoGene
|
cdd
(
EG10137
)
|
|
Number of removed
|
0 aa cleaved
|
|
SWISS-PROT
(
Show details
[
2
more]
)
|
Entry name(Acc.no)
|
CDD_ECOLI
(
P13652
)
|
|
- Protein name
|
Cytidine deaminase
|
|
- Synonyms
|
EC 3.5.4.5, Cytidine aminohydrolase, CDA
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- Gene name
|
Name=cdd; OrderedLocusNames=b2143, SF2228, S2357;
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Homology Analysis
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BLAST
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Bacteria
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GTOP
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cdd
(
homologous genes of other bacterias
)
|
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PDB
(database updated :
2007.02.20
)
|
|
PSI-BLAST
|
Chain , Cytidine Deaminase (Cda) (E.C.3.5.4.5) Complexed With 3,4-Dihydrozebularine (Dhz)
|
|
SWISS-PROT
(database updated :
2007.02.20
)
|
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BLAST
|
Cytidine deaminase (Cytidine aminohydrolase) (CDA)
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PSI-BLAST
|
Cytidine deaminase
|
|
nr
(database updated :
2007.02.20
)
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BLAST
|
cytidine deaminase [Escherichia coli K12]
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Pfam 28.0
(database updated :
2015-05
)
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Pfam
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|
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PROSITE
|
|
PROSITE
|
ASN_GLYCOSYLATION
PKC_PHOSPHO_SITE
CK2_PHOSPHO_SITE
MYRISTYL
PROKAR_LIPOPROTEIN
CYT_DCMP_DEAMINASES
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MMBR References
|
J. Biochem. (Tokyo) 1970;13:180-187.
The mode of action of 5-aza-2'-deoxycytidine in Escherichia coli.
Doskocil, J., and F. Sorm.
|
Mol Gen Genet. 1981;182(1):154-8.
Fusion of the lac genes to the promotor for the cytidine deaminase gene of Escherichia coli K-12.
Josephsen J, Hammer-Jespersen K.
(
6455590
)
|
J Bacteriol. 1983;154(1):72-5.
Mapping of the gene for cytidine deaminase (cdd) in Escherichia coli K-12.
Josephsen J, Hammer-Jespersen K, Hansen TD.
(
6339482
)
|
Mol Gen Genet. 1984;197(1):175-81.
Mapping of markers in the gyrA-his region of Escherichia coli.
Middendorf A, Schweizer H, Vreemann J, Boos W.
(
6392823
)
|
J Bacteriol. 1971;105(2):666-72.
Deoxycytidine triphosphate deaminase: characterization of an Escherichia coli mutant deficient in the enzyme.
O'Donovan GA, Edlin G, Fuchs JA, Neuhard J, Thomassen E.
(
5541540
)
|
Mol Gen Genet. 1981;184(3):508-18.
Mapping of mglB, the structural gene of the galactose-binding protein of Escherichia coli.
Boos W, Steinacher I, Engelhardt-Altendorf D.
(
6278261
)
|
J Bacteriol. 1980;144(3):952-6.
Construction of an Escherichia coli strain unable to synthesize putrescine, spermidine, or cadaverine: characterization of two genes controlling lysine decarboxylase.
Tabor H, Hafner EW, Tabor CW.
(
7002915
)
|
Biochemistry. 1992;31(17):4168-74.
Cloning and nucleotide sequence of the Escherichia coli cytidine deaminase (ccd) gene.
Yang C, Carlow D, Wolfenden R, Short SA.
(
1567863
)
|
| Sequences |
Amino acid
FASTA format
|
0001 MHPRFQTAFA QLADNLQSAL EPILADKYFP ALLTGEQVSS LKSATGLDED ALAFALLPLA AACARTPLSN
0071 FNVGAIARGV SGTWYFGANM EFIGATMQQT VHAEQSAISH AWLSGEKALA AITVNYTPCG HCRQFMNELN
0141 SGLDLRIHLP GREAHALRDY LPDAFGPKDL EIKTLLMDEQ DHGYALTGDA LSQAAIAAAN RSHMPYSKSP
0211 SGVALECKDG RIFSGSYAEN AAFNPTLPPL QGALILLNLK GYDYPDIQRA VLAEKADAPL IQWDATSATL
0281 KALGCHSIDR VLLA
|
Nucleotide
FASTA format
View sequence out neighbor 100bp
|
-100 TATGTTTCAC GCGTTGCATA ATTAATGAGA
-070 TTCAGATCAC ATATAAAGCC ACAACGGGTT CGTAAACTGT TATCCCATTA CATGATTATG AGGCAACGCC
0001 atgcatccac gttttcaaac cgcttttgcc caacttgcgg ataacttgca atctgcactg gaacctattc
0071 tggcagacaa gtacttcccc gctttgttga ccggggagca agtctcatcg ctgaagagcg caacggggct
0141 ggacgaagac gcgctggcat tcgcactact tccgctggcg gcggcctgtg cgcgtacgcc attgtcgaat
0211 tttaatgttg gcgcaattgc gcgcggtgtg agcggaacct ggtatttcgg tgccaatatg gaatttattg
0281 gtgcgacaat gcagcaaacc gttcatgccg aacaaagcgc gatcagccac gcctggttga gtggtgaaaa
0351 agcgcttgca gccatcaccg ttaactacac gccttgtggt cactgccgtc agtttatgaa tgaactgaac
0421 agcggtctgg atctgcgtat tcatctgccg ggccgcgagg cacacgcgct gcgtgactat ctgccagatg
0491 cctttgggcc gaaagatctg gagattaaaa cgctgctgat ggacgaacag gatcacggct atgcgctgac
0561 gggtgatgcg ctttctcagg cagcgattgc ggcggcaaac cgttcgcaca tgccttacag taagtcgcca
0631 agcggtgtcg cgctggaatg taaagacggt cgtattttca gtggcagcta cgctgaaaac gccgcattca
0701 acccgactct gccaccgttg cagggagcgt taattctgtt gaatctcaag ggttatgatt acccggatat
0771 ccagcgcgcg gttctggcag aaaaagccga tgcgccgttg attcagtggg atgccacctc cgcaacgctg
0841 aaagctctcg gctgtcacag tatcgaccga gtgcttctcg cttaaGCCTG GTGCCGGATG CGGCGTGAAC
0911 GCCTTGTCCG GCTTGCCAGC CCTCTCCTGG TGTCGAAATT CCCGGCAAAC AGTTTGCCGT TTCTTGCGCA
0981 AAACC
|
