|
PEC Original Annotations
|
|
Essentiality
|
|
Class
|
non-essential
|
|
References (PMID)
|
Escherichia coli and Salmonella, Cellular and Molecular Biology Second Edition. ASM Press. 1996
Neidhart, F.C.
|
|
|
Deletion
|
OCL73-3
(D)
,
OCL73-4
(D)
|
|
Related gene (W3110 PEC)
|
|
Gene Search
|
Search MG1655 PEC by gene name:
bcr
|
|
Related strains
|
|
Strains Search
|
Search strains by gene name:
bcr
Search strains by all related name:
bcr b2182 bicA bicR ECK2176 JW5363 sur suxA
|
General information (Go to Linear View: )
|
|
Gene Name
|
bcr
|
|
Alternative name
|
b2182,bicA,bicR,ECK2176,JW5363,sur,suxA
|
|
Location, Length
|
2,276,592 - 2,277,782
(
-
)
;
49.07
min
;
1191
(bp) ,
396
(aa)
|
|
Product
|
bicyclomycin/cysteine/sulfonamide efflux transporter
|
|
Operon Name
|
bcr
|
|
Note
|
bicyclomycin resistance protein; transmembrane protein; GO_component: GO:0009274 - peptidoglycan-based cell wall; GO_component: GO:0019866 - organelle inner membrane; GO_process: GO:0042493 - response to drug
|
|
Function
|
transport; Drug/analog sensitivity
|
|
Gene Ontology
|
GO:0005215
;
transporter activity ( bcr )
GO:0005886
;
plasma membrane ( bcr )
GO:0006810
;
transport ( bcr )
GO:0015238
;
drug transporter activity ( bcr )
GO:0015893
;
drug transport ( bcr )
GO:0016020
;
membrane ( bcr )
GO:0016021
;
integral to membrane ( bcr )
GO:0046677
;
response to antibiotic ( bcr )
|
|
PID
|
1788509
|
EC number
(KEGG Pathway)
|
|
|
SWISS-PROT
(
Show details
[
2
more]
)
|
Entry name(Acc.no)
|
BCR_ECOLI
(
P28246
)
|
|
- Protein name
|
Bicyclomycin resistance protein
|
|
- Synonyms
|
Sulfonamide resistance protein
|
|
- Gene name
|
Name=bcr; Synonyms=bicA, bicR, sur, suxA; OrderedLocusNames=b2182;
|
|
Homology Analysis
|
|
BLAST
|
|
Bacteria
|
|
GTOP
|
bcr
(
homologous genes of other bacterias
)
|
|
PDB
(database updated :
2007.02.20
)
|
|
PSI-BLAST
|
Chain A, Structure Of The Multidrug Transporter Emrd From Escherichia Coli
|
|
SWISS-PROT
(database updated :
2007.02.20
)
|
|
BLAST
|
Bicyclomycin resistance protein
|
|
PSI-BLAST
|
High-affinity glucose transporter SNF3
|
|
nr
(database updated :
2007.02.20
)
|
|
BLAST
|
COG0477: Permeases of the major facilitator superfamily [Escherichia coli B7A]
|
|
Pfam 28.0
(database updated :
2015-05
)
|
|
Pfam
|
|
|
PROSITE
|
|
PROSITE
|
PKC_PHOSPHO_SITE
MYRISTYL
AMIDATION
PROKAR_LIPOPROTEIN
|
|
MMBR References
|
Gene. 1993;127(1):117-20.
Cloning and sequence analysis of an Escherichia coli gene conferring bicyclomycin resistance.
Bentley J, Hyatt LS, Ainley K, Parish JH, Herbert RB, White GR.
(
8486276
)
|
| Sequences |
Amino acid
FASTA format
|
0001 MTTRQHSSFA IVFILGLLAM LMPLSIDMYL PALPVISAQF GVPAGSTQMT LSTYILGFAL GQLIYGPMAD
0071 SFGRKPVVLG GTLVFAAAAV ACALANTIDQ LIVMRFFHGL AAAAASVVIN ALMRDIYPKE EFSRMMSFVM
0141 LVTTIAPLMA PIVGGWVLVW LSWHYIFWIL ALAAILASAM IFFLIKETLP PERRQPFHIR TTIGNFAALF
0211 RHKRVLSYML ASGFSFAGMF SFLSAGPFVY IEINHVAPEN FGYYFALNIV FLFVMTIFNS RFVRRIGALN
0281 MFRSGLWIQF IMAAWMVISA LLGLGFWSLV VGVAAFVGCV SMVSSNAMAV ILDEFPHMAG TASSLAGTFR
0351 FGIGAIVGAL LSLATFNSAW PMIWSIAFCA TSSILFCLYA SRPKKR
|
Nucleotide
FASTA format
View sequence out neighbor 100bp
|
-100 tacgctggat gctgatttag cccccggtga
-070 atatcgtccg ttaactgaag aagaaattgc cagcgtcgtc taacttttca atgactttca ggagcccgtt
0001 gtgaccaccc gacagcattc gtcgtttgct attgttttta tccttggcct gctggccatg ttgatgccgc
0071 tgtcgattga tatgtatctg cccgcgctac cggtaatttc agcgcagttt ggcgtaccgg cgggcagtac
0141 gcagatgacc ctcagtactt atattctggg ctttgcgttg gggcagttaa tctacgggcc gatggcagac
0211 agcttcgggc gtaagccggt ggtgctcggc ggtacgctgg tgtttgccgc cgccgcggtg gcgtgtgcgt
0281 tggcaaacac catcgatcag ctgattgtga tgcgtttctt ccacgggctg gctgcggctg cggccagcgt
0351 ggtcattaac gccctgatgc gcgatattta cccgaaagaa gagttctcgc ggatgatgtc gtttgtcatg
0421 ctggtgacaa ccattgcacc gctgatggca ccgatagttg gcggctgggt gctggtgtgg ctgagctggc
0491 attacatctt ctggatcctg gcattagcgg cgattctggc ttcggcaatg attttcttcc tgattaaaga
0561 aaccttacca ccggagcgtc gtcagccatt tcacattcgt accactattg gtaactttgc ggcgctgttc
0631 cgccataaac gtgtcctgag ctacatgctt gccagtggtt tcagctttgc cgggatgttc tcattcttaa
0701 gcgccggacc gtttgtttat attgaaatta accacgtcgc gccggaaaac tttggttatt actttgcgct
0771 aaacattgtt tttctgttcg tgatgaccat ctttaacagc cgcttcgtcc gccgcattgg cgcgttaaat
0841 atgttccgct cggggttgtg gatacaattt attatggcag cgtggatggt catcagtgcg ctgctggggc
0911 tgggattttg gtcgctggtg gttggcgttg cggcgtttgt gggctgcgtg tcgatggtgt catccaatgc
0981 gatggcggtc attcttgatg agtttcccca tatggcggga acggcatctt cgctggcagg aaccttccgt
1051 tttggcatag gggcaattgt tggcgcattg ctttctcttg cgacctttaa ctctgcatgg ccgatgattt
1121 ggtcaattgc attctgcgca accagctcca ttctcttctg tctgtacgcc agtcggccga aaaaacggtg
1191 atctattgca caacgaggaa gctaaaaggc ttcctttgtt gatgcatgtc aaccacaaat ctatcattcc
1261 cccgatatat gtttatttta tgtaaaatca a
|
