|
PEC Original Annotations
|
|
Essentiality
|
|
Class
|
non-essential
|
|
References (PMID)
|
Escherichia coli and Salmonella, Cellular and Molecular Biology Second Edition. ASM Press. 1996
Neidhart, F.C.
|
|
|
Deletion
|
14
(LD)
,
OCL70
(D)
,
OCL70,72-4 (LD 14C_P/O)
(D)
|
|
Related gene (W3110 PEC)
|
|
Gene Search
|
Search MG1655 PEC by gene name:
rcsC
|
|
Related strains
|
|
Strains Search
|
Search strains by gene name:
rcsC
Search strains by all related name:
rcsC b2218 ECK2211 JW5917 JW5920
|
General information (Go to Linear View: )
|
|
Gene Name
|
rcsC
|
|
Alternative name
|
b2218,ECK2211,JW5917,JW5920
|
|
Location, Length
|
2,315,049 - 2,317,898
(
-
)
;
49.90
min
;
2850
(bp) ,
949
(aa)
|
|
Product
|
hybrid sensory kinase in two-component regulatory system with RcsB and YojN
|
|
Operon Name
|
rcsC
|
|
Note
|
sensor for ctr capsule biosynthesis, probable histidine kinase acting on RcsB; GO_component: GO:0009274 - peptidoglycan-based cell wall; GO_component: GO:0019866 - organelle inner membrane; GO_function: GO:0042280 - cell surface antigen activity, host-interacting; GO_process: GO:0009242 - colanic acid biosynthetic process; GO_process: GO:0006464 - protein modification process
|
|
Function
|
enzyme; Surface polysaccharides & antigens
|
|
Gene Ontology
|
GO:0000155
;
two-component sensor activity ( rcsC )
GO:0000156
;
two-component response regulator activity ( rcsC )
GO:0000160
;
two-component signal transduction system (phosphorelay) ( rcsC )
GO:0004673
;
protein histidine kinase activity ( rcsC )
GO:0004871
;
signal transducer activity ( rcsC )
GO:0005524
;
ATP binding ( rcsC )
GO:0005886
;
plasma membrane ( rcsC )
GO:0006355
;
regulation of transcription, DNA-dependent ( rcsC )
GO:0007165
;
signal transduction ( rcsC )
GO:0016020
;
membrane ( rcsC )
GO:0016021
;
integral to membrane ( rcsC )
GO:0016301
;
kinase activity ( rcsC )
GO:0016310
;
phosphorylation ( rcsC )
GO:0016740
;
transferase activity ( rcsC )
GO:0016772
;
transferase activity, transferring phosphorus-containing groups ( rcsC )
GO:0018106
;
peptidyl-histidine phosphorylation ( rcsC )
|
|
PID
|
145693157
|
EC number
(KEGG Pathway)
|
|
|
SWISS-PROT
(
Show details
[
2
more]
)
|
Entry name(Acc.no)
|
RCSC_ECOLI
(
P14376
;
P76457; P97170; P97202; Q47586
)
|
|
- Protein name
|
Sensor protein rcsC
|
|
- Synonyms
|
EC 2.7.3.-, Capsular synthesis regulator component C
|
|
- Gene name
|
Name=rcsC; OrderedLocusNames=b2218;
|
|
Homology Analysis
|
|
BLAST
|
|
Bacteria
|
|
GTOP
|
rcsC
(
homologous genes of other bacterias
)
|
|
PDB
(database updated :
2007.02.20
)
|
|
PSI-BLAST
|
Chain A, Solution Structure Of The E.Coli Rcsc C-Terminus
|
|
SWISS-PROT
(database updated :
2007.02.20
)
|
|
BLAST
|
Sensor kinase protein rcsC
|
|
PSI-BLAST
|
Sensor kinase protein rcsC
|
|
nr
(database updated :
2007.02.20
)
|
|
BLAST
|
hybrid sensory kinase in two-component regulatory system with RcsB and YojN [Escherichia coli K12]
|
|
Pfam 28.0
(database updated :
2015-05
)
|
|
Pfam
|
|
|
PROSITE
|
|
PROSITE
|
ASN_GLYCOSYLATION
PKC_PHOSPHO_SITE
CK2_PHOSPHO_SITE
MYRISTYL
AMIDATION
|
|
MMBR References
|
J Bacteriol. 1985;162(3):1111-9.
Regulation of capsular polysaccharide synthesis in Escherichia coli K-12: characterization of three regulatory genes.
Gottesman S, Trisler P, Torres-Cabassa AS.
(
3888955
)
|
Mol Microbiol. 1997;25(5):913-31.
Positive control of the two-component RcsC/B signal transduction network by DjlA: a member of the DnaJ family of molecular chaperones in Escherichia coli.
Kelley WL, Georgopoulos C.
(
9364917
)
|
J Bacteriol. 1997;179:330-338
Identification and characterization of hydrogen peroxide-sensitive mutants of Escherichia coli: genes that require OxyR for expression.
Mukhopadhyay, S., and H. E. Schellhorn.
|
J Bacteriol. 1996;178:1204-1206
Osmotic induction of capsule synthesis in Escherichia coli.
Sledjeski, D. D., and S. Gottesman.
|
J Bacteriol. 1990;172(2):659-69.
RcsB and RcsC: a two-component regulator of capsule synthesis in Escherichia coli.
Stout V, Gottesman S.
(
2404948
)
|
J Bacteriol. 1988;170(6):2599-611.
Fine-structure mapping and identification of two regulators of capsule synthesis in Escherichia coli K-12.
Brill JA, Quinlan-Walshe C, Gottesman S.
(
2836365
)
|
| Sequences |
Amino acid
FASTA format
|
0001 MKYLASFRTT LKASRYMFRA LALVLWLLIA FSSVFYIVNA LHQRESEIRQ EFNLSSDQAQ RFIQRTSDVM
0071 KELKYIAENR LSAENGVLSP RGRETQADVP AFEPLFADSD CSAMSNTWRG SLESLAWFMR YWRDNFSAAY
0141 DLNRVFLIGS DNLCMANFGL RDMPVERDTA LKALHERINK YRNAPQDDSG SNLYWISEGP RPGVGYFYAL
0211 TPVYLANRLQ ALLGVEQTIR MENFFLPGTL PMGVTILDEN GHTLISLTGP ESKIKGDPRW MQERSWFGYT
0281 EGFRELVLKK NLPPSSLSIV YSVPVDKVLE RIRMLILNAI LLNVLAGAAL FTLARMYERR IFIPAESDAL
0351 RLEEHEQFNR KIVASAPVGI CILRTADGVN ILSNELAHTY LNMLTHEDRQ RLTQIICGQQ VNFVDVLTSN
0421 NTNLQISFVH SRYRNENVAI CVLVDVSSRV KMEESLQEMA QAAEQASQSK SMFLATVSHE LRTPLYGIIG
0491 NLDLLQTKEL PKGVDRLVTA MNNSSSLLLK IISDILDFSK IESEQLKIEP REFSPREVMN HITANYLPLV
0561 VRKQLGLYCF IEPDVPVALN GDPMRLQQVI SNLLSNAIKF TDTGCIVLHV RADGDYLSIR VRDTGVGIPA
0631 KEVVRLFDPF FQVGTGVQRN FQGTGLGLAI CEKLISMMDG DISVDSEPGM GSQFTVRIPL YGAQYPQKKG
0701 VEGLSGKRCW LAVRNASLCQ FLETSLQRSG IVVTTYEGQE PTPEDVLITD EVVSKKWQGR AVVTFCRRHI
0771 GIPLEKAPGE WVHSVAAPHE LPALLARIYL IEMESDDPAN ALPSTDKAVS DNDDMMILVV DDHPINRRLL
0841 ADQLGSLGYQ CKTANDGVDA LNVLSKNHID IVLSDVNMPN MDGYRLTQRI RQLGLTLPVI GVTANALAEE
0911 KQRCLESGMD SCLSKPVTLD VIKQTLTLYA ERVRKSRDS
|
Nucleotide
FASTA format
View sequence out neighbor 100bp
|
-100 ggtgtatcat attccagaga agagagaaca
-070 ttgcggtaac acgcttttac cgctacctta accacactcc atcggtcacc tgaggcggag cttcgcccct
0001 ttgaaatacc ttgcttcttt tcgtacaacc ctgaaagcct cgcgctacat gttcagagca ttggcgttag
0071 tgctctggct gttgattgct ttttcatccg ttttttacat cgttaatgcg ttacatcagc gagaatcgga
0141 aattcgtcag gaatttaatc tgagttccga tcaggctcag cgctttattc aacgcacctc tgatgtgatg
0211 aaagagctga agtacatcgc cgaaaatcgc ttatcggcag aaaacggtgt gctttccccg cgtggacgag
0281 aaacgcaggc ggatgtgcct gcgtttgaac cgctgtttgc cgactccgat tgttccgcaa tgagtaacac
0351 ctggcgaggt tctctggagt cattggcgtg gtttatgcgc tactggcgcg ataatttttc tgcggcttac
0421 gatctaaacc gggtattttt aatcggcagc gataacctct gcatggccaa tttcggtctg cgtgatatgc
0491 cagtggaacg cgataccgcg ttgaaagctt tgcatgaacg catcaataaa tatcgaaatg caccacaaga
0561 tgatagcggc agtaacctct actggatcag cgaaggtccg cgccctggcg tcgggtattt ttacgcgttg
0631 acgccagttt atctggcgaa ccggttgcag gcgcttttgg gtgtcgagca gaccatccgg atggagaact
0701 ttttcttacc gggtacgttg ccgatggggg ttaccattct tgatgaaaat ggtcataccc tgatttcgct
0771 taccggacca gaaagtaaaa ttaagggcga tcctcgctgg atgcaggaac gctcctggtt tggctatacg
0841 gaagggttcc gggagctggt gctgaagaaa aatctgccac cctcatcgct aagcatcgtg tattcggtgc
0911 cggttgataa ggtgctggaa cgcattcgca tgttgatcct taacgcaatt ttgctgaatg tgcttgccgg
0981 agctgcattg tttactctcg cacggatgta cgagcgacgt attttcattc cggcggaaag cgacgccctg
1051 cgactggaag aacatgagca gttcaatcgc aagattgtcg cctccgcgcc agtgggtatc tgcattttgc
1121 gtaccgctga tggcgtcaat attttaagta acgaactggc gcatacctat ctcaatatgc ttacgcatga
1191 ggaccgccaa cgactgacgc aaattatctg tgggcagcag gtcaattttg ttgatgtcct gaccagcaac
1261 aataccaatc tgcaaatcag cttcgtccat tcgcgctatc gtaatgaaaa cgtggccatt tgtgtgctgg
1331 tggatgtttc ttcgcgcgtg aagatggaag agtcgttgca ggagatggca caagcagcgg aacaggcgag
1401 ccagtcaaaa tcgatgttcc ttgccaccgt cagtcatgag ctgcgaacgc cgctgtatgg cattatcggt
1471 aacctggatc tgttgcaaac caaagagtta ccgaaaggcg tcgatcggct ggtgacggca atgaacaact
1541 cttccagcct gttgttgaaa attatcagcg atattctcga tttctcgaag attgaatcgg aacagttgaa
1611 gatcgaaccg cgtgagtttt caccgcgtga agtgatgaac cacatcaccg ccaactattt accgctggtg
1681 gtacgcaagc agttaggctt gtactgcttt attgaaccgg atgtgccagt ggccttaaat ggcgacccga
1751 tgcgtttaca gcaggtcatc tccaacctgt tgagtaacgc cataaaattc accgataccg gctgtatagt
1821 tttgcatgtt cgcgcggatg gcgattatct ctctatccgt gttcgcgata ccggcgtggg gataccggcg
1891 aaagaagtgg tgcgcttgtt tgatcccttc ttccaggtcg gaacgggcgt acagcgtaat ttccagggga
1961 ccggtctggg tctggcgatt tgtgaaaaac tgatcagcat gatggacggc gatatctcgg tagattcaga
2031 accgggaatg ggcagccagt ttaccgtgcg tattccgttg tacggcgctc agtacccgca gaaaaaaggc
2101 gtggaagggt tgagtggtaa acgctgctgg ctggcggtcc gcaatgcgtc gctctgtcag ttcctggaaa
2171 ccagtttgca gcgcagcggc atcgtcgtta caacatacga agggcaggaa ccgactcccg aagatgtgtt
2241 gatcactgac gaggtagtga gtaaaaaatg gcagggcaga gcggtagtga ccttctgtcg tcgccatatt
2311 ggtattccgc tggagaaagc gccaggggag tgggtacaca gtgtggctgc tccgcatgag ctaccggcat
2381 tgttggcgcg tatttatttg atcgagatgg agagcgacga tcctgctaac gctctgccgt caacggacaa
2451 agcggtcagc gataatgacg atatgatgat tctggtcgtg gatgatcatc cgattaaccg gcgtttgctg
2521 gcagatcagt tgggatcgtt gggctatcaa tgtaaaaccg cgaatgatgg cgtcgatgcg cttaatgtac
2591 ttagcaagaa tcatattgat atcgtgctta gcgacgtcaa catgccaaat atggatggtt accgcttgac
2661 gcaacgcatt cgtcagttgg gactgacgtt gccggtaatc ggagtaactg ctaatgcgtt ggctgaagag
2731 aagcagcggt gtctggagtc cggtatggac agctgcctgt cgaagccggt aacgctggat gtgataaaac
2801 agacgctgac gttatatgcc gagagggtca ggaaatcgcg ggattcgtag gacggataag gcgtttacgc
2871 cgcatccggc attcagtgca aatgccagat gcgacgctga cgcgtcttat ctggcctact ttaatgtaat
2941 ttgttgaaat
|
