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PEC Original Annotations
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Essentiality
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Class
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non-essential
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References (PMID)
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Biochim Biophys Acta. 1990;1046(1):97-105.
Characterization of FadL-specific fatty acid binding in Escherichia coli.
Black PN.
(
2204431
)
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Deletion
|
OCL63
(D)
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Related gene (W3110 PEC)
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Gene Search
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Search MG1655 PEC by gene name:
fadL
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Related strains
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Strains Search
|
Search strains by gene name:
fadL
Search strains by all related name:
fadL b2344 ECK2338 JW2341 ttr
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General information (Go to Linear View: )
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Gene Name
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fadL
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Alternative name
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b2344,ECK2338,JW2341,ttr
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Location, Length
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2,459,328 - 2,460,668
(
+
)
;
53.01
min
;
1341
(bp) ,
446
(aa)
|
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Product
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long-chain fatty acid outer membrane transporter
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Operon Name
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fadL
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Note
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long-chain fatty acid transport protein (outer membrane flp protein); GO_component: GO:0009274 - peptidoglycan-based cell wall; GO_component: GO:0009279 - cell outer membrane; GO_process: GO:0019395 - fatty acid oxidation
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Function
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enzyme; Transport of small molecules: Carbohydrates, organic acids, alcohols
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Gene Ontology
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GO:0005215
;
transporter activity ( fadL )
GO:0006810
;
transport ( fadL )
GO:0006869
;
lipid transport ( fadL )
GO:0009279
;
cell outer membrane ( fadL )
GO:0009597
;
detection of virus ( fadL )
GO:0016020
;
membrane ( fadL )
GO:0016021
;
integral to membrane ( fadL )
GO:0019867
;
outer membrane ( fadL )
GO:0046718
;
entry of virus into host cell ( fadL )
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PID
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145693163
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EC number
(KEGG Pathway)
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Verified Protein Starts
(data
compiled from literature and appropriate citations are available from EcoGene)
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EcoGene
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fadL
(
EG10280
)
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Number of removed
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25 aa cleaved
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SWISS-PROT
(
Show details
[
2
more]
)
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Entry name(Acc.no)
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FADL_ECOLI
(
P10384
;
P77697
)
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- Protein name
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Long-chain fatty acid transport protein precursor
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- Synonyms
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Outer membrane fadL protein, Outer membrane flp protein
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- Gene name
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Name=fadL; Synonyms=ttr; OrderedLocusNames=b2344;
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MMBR References
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J Bacteriol. 1986;168(2):534-40.
New locus (ttr) in Escherichia coli K-12 affecting sensitivity to bacteriophage T2 and growth on oleate as the sole carbon source.
Morona R, Henning U.
(
3536849
)
|
Proc Natl Acad Sci U S A. 1978;75:3377-3381
Transport of long-chain fatty acids by Escherichia coli: mapping and characterization of mutants in the fadL gene.
Nunn, W. D., and R. W. Simons.
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J Bacteriol. 1988;170(6):2850-4.
The fadL gene product of Escherichia coli is an outer membrane protein required for uptake of long-chain fatty acids and involved in sensitivity to bacteriophage T2.
Black PN.
(
3286621
)
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J Biol Chem. 1985;260:1780-1789
Long-chain fatty acid transport in Escherichia coli. Cloning, mapping, and expression of the fadL gene.
Black, P. N., S. F. Kianian, C. C. DiRusso, and W. D. Nunn.
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Mol Microbiol. 1988;2(3):363-70.
Nucleotide sequencing and expression of the fadL gene involved in long-chain fatty acid transport in Escherichia coli.
Said B, Ghosn CR, Vu L, Nunn WD.
(
2840553
)
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| Sequences |
Amino acid
FASTA format
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0001 MSQKTLFTKS ALAVAVALIS TQAWSAGFQL NEFSSSGLGR AYSGEGAIAD DAGNVSRNPA LITMFDRPTF
0071 SAGAVYIDPD VNISGTSPSG RSLKADNIAP TAWVPNMHFV APINDQFGWG ASITSNYGLA TEFNDTYAGG
0141 SVGGTTDLET MNLNLSGAYR LNNAWSFGLG FNAVYARAKI ERFAGDLGQL VAGQIMQSPA GQTQQGQALA
0211 ATANGIDSNT KIAHLNGNQW GFGWNAGILY ELDKNNRYAL TYRSEVKIDF KGNYSSDLNR AFNNYGLPIP
0281 TATGGATQSG YLTLNLPEMW EVSGYNRVDP QWAIHYSLAY TSWSQFQQLK ATSTSGDTLF QKHEGFKDAY
0351 RIALGTTYYY DDNWTFRTGI AFDDSPVPAQ NRSISIPDQD RFWLSAGTTY AFNKDASVDV GVSYMHGQSV
0421 KINEGPYQFE SEGKAWLFGT NFNYAF
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Nucleotide
FASTA format
View sequence out neighbor 100bp
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-100 CTGGTCTGAT TTCTAAGATG TACCTCAGAC
-070 CCTACACTTC GCGCTCCTGT TACAGCACGT AACATAGTTT GTATAAAAAT AAATCATTGA GGTTATGGTC
0001 atgagccaga aaaccctgtt tacaaagtct gctctcgcag tcgcagtggc acttatctcc acccaggcct
0071 ggtcggcagg ctttcagtta aacgaatttt cttcctctgg cctgggccgg gcttattcag gggaaggcgc
0141 aattgccgat gatgcaggta acgtcagccg taaccccgca ttgattacta tgtttgaccg cccgacattt
0211 tctgcgggtg cggtttatat tgacccggat gtaaatatca gcggaacgtc tccatctggt cgtagcctga
0281 aagccgataa catcgcgcct acggcatggg ttccgaacat gcactttgtt gcaccgatta acgaccaatt
0351 tggttggggc gcttctatta cctctaacta tggtctggct acagagttta acgatactta tgcaggcggc
0421 tctgtcgggg gtacaaccga ccttgaaacc atgaacctga acttaagcgg tgcgtatcgc ttaaataatg
0491 catggagctt tggtcttggt ttcaacgccg tctacgctcg cgcgaaaatt gaacgtttcg caggcgatct
0561 ggggcagttg gttgctggcc aaattatgca atctcctgct ggccaaactc agcaagggca agcattggca
0631 gctaccgcca acggtattga cagtaatacc aaaatcgctc atctgaacgg taaccagtgg ggctttggct
0701 ggaacgccgg aatcctgtat gaactggata aaaataaccg ctatgcactg acctaccgtt ctgaagtgaa
0771 aattgacttc aaaggtaact acagcagcga tcttaatcgt gcgtttaata actacggttt gccaattcct
0841 accgcgacag gtggcgcaac gcaatcgggt tatctgacgc tgaacctgcc tgaaatgtgg gaagtgtcag
0911 gttataaccg tgttgatcca cagtgggcga ttcactatag cctggcttac accagctgga gtcagttcca
0981 gcagctgaaa gcgacctcaa ccagtggcga cacgctgttc cagaaacatg aaggctttaa agatgcttac
1051 cgcatcgcgt tgggtaccac ttattactac gatgataact ggaccttccg taccggtatc gcctttgatg
1121 acagcccagt tcctgcacag aatcgttcta tctccattcc ggaccaggac cgtttctggc tgagtgcagg
1191 tacgacttac gcatttaata aagatgcttc agtcgacgtt ggtgtttctt atatgcacgg tcagagcgtg
1261 aaaattaacg aaggcccata ccagttcgag tctgaaggta aagcctggct gttcggtact aactttaact
1331 acgcgttctg aTAACGCGTT CGCCTGGATA AAGTCACCTG CATAGCAGGT GACTTTAACT CCCCCACTTC
1401 ACCGAAAGTA GTGTCCTCAT TGCTTACCTC CTGAGTTTTG C
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