|
PEC Original Annotations
|
|
Essentiality
|
|
Class
|
non-essential
|
|
References (PMID)
|
Escherichia coli and Salmonella, Cellular and Molecular Biology Second Edition. ASM Press. 1996
Neidhart, F.C.
|
|
|
Deletion
|
OCR10,11-16 (BK5-16 / AK7-16)
(D)
,
OCR11
(D)
|
|
Related gene (W3110 PEC)
|
|
Gene Search
|
Search MG1655 PEC by gene name:
hemE
|
|
Related strains
|
|
Strains Search
|
Search strains by gene name:
hemE
Search strains by all related name:
hemE b3997 ECK3989 hemC JW3961
|
General information (Go to Linear View: )
|
|
Gene Name
|
hemE
|
|
Alternative name
|
b3997,ECK3989,hemC,JW3961
|
|
Location, Length
|
4,195,739 - 4,196,803
(
+
)
;
90.43
min
;
1065
(bp) ,
354
(aa)
|
|
Product
|
uroporphyrinogen decarboxylase
|
|
Operon Name
|
nudC-hemE-nfi
|
|
Note
|
|
|
Function
|
enzyme; Biosynthesis of cofactors, carriers: Heme, porphyrin
|
|
Gene Ontology
|
GO:0004418
;
hydroxymethylbilane synthase activity ( hemC )
GO:0004853
;
uroporphyrinogen decarboxylase activity ( hemE )
GO:0005515
;
protein binding ( hemE )
GO:0005737
;
cytoplasm ( hemE )
GO:0006779
;
porphyrin biosynthetic process ( hemC )
GO:0006779
;
porphyrin biosynthetic process ( hemE )
GO:0016740
;
transferase activity ( hemC )
GO:0016829
;
lyase activity ( hemE )
GO:0016831
;
carboxy-lyase activity ( hemE )
GO:0033014
;
tetrapyrrole biosynthetic process ( hemC )
|
|
PID
|
2367337
|
EC number
(KEGG Pathway)
|
4.1.1.37
|
|
SWISS-PROT
(
Show details
[
2
more]
)
|
Entry name(Acc.no)
|
DCUP_ECOLI
(
P29680
;
P78135
)
|
|
- Protein name
|
Uroporphyrinogen decarboxylase
|
|
- Synonyms
|
EC 4.1.1.37, URO-D, UPD
|
|
- Gene name
|
Name=hemE; OrderedLocusNames=b3997;
|
|
Homology Analysis
|
|
BLAST
|
|
Bacteria
|
|
GTOP
|
hemE
(
homologous genes of other bacterias
)
hemC
(
homologous genes of other bacterias
)
|
|
PDB
(database updated :
2007.02.20
)
|
|
PSI-BLAST
|
Chain A, Uroporphyrinogen Decarboxylase
|
|
SWISS-PROT
(database updated :
2007.02.20
)
|
|
BLAST
|
Uroporphyrinogen decarboxylase
|
|
PSI-BLAST
|
Uroporphyrinogen decarboxylase
|
|
nr
(database updated :
2007.02.20
)
|
|
BLAST
|
uroporphyrinogen decarboxylase [Escherichia coli K12]
|
|
Pfam 28.0
(database updated :
2015-05
)
|
|
Pfam
|
|
|
PROSITE
|
|
PROSITE
|
PKC_PHOSPHO_SITE
CK2_PHOSPHO_SITE
MYRISTYL
AMIDATION
UROD_1
UROD_2
|
|
MMBR References
|
J Bacteriol. 1993;175(23):7749-50.
Location of the hemE gene on the physical map of Escherichia coli.
Ineichen G, Biel AJ.
(
8244953
)
|
Gene. 1993;133(1):109-13.
Cloning and sequencing of the hemE gene encoding uroporphyrinogen III decarboxylase (UPD) from Escherichia coli K-12.
Nishimura K, Nakayashiki T, Inokuchi H.
(
8224882
)
|
J Bacteriol. 1975;124(3):1205-12.
Uroporphyrin-accumulating mutant of Escherichia coli K-12.
Sasarman A, Chartrand P, Proschek R, Desrochers M, Tardif D, Lapointe C.
(
1104578
)
|
| Sequences |
Amino acid
FASTA format
|
0001 MTELKNDRYL RALLRQPVDV TPVWMMRQAG RYLPEYKATR AQAGDFMSLC KNAELACEVT LQPLRRYPLD
0071 AAILFSDILT VPDAMGLGLY FEAGEGPRFT SPVTCKADVD KLPIPDPEDE LGYVMNAVRT IRRELKGEVP
0141 LIGFSGSPWT LATYMVEGGS SKAFTVIKKM MYADPQALHA LLDKLAKSVT LYLNAQIKAG AQAVMIFDTW
0211 GGVLTGRDYQ QFSLYYMHKI VDGLLRENDG RRVPVTLFTK GGGQWLEAMA ETGCDALGLD WTTDIADARR
0281 RVGNKVALQG NMDPSMLYAP PARIEEEVAT ILAGFGHGEG HVFNLGHGIH QDVPPEHAGV FVEAVHRLSE
0351 QYHR
|
Nucleotide
FASTA format
View sequence out neighbor 100bp
|
-100 CACCGTAGCG CGCCGTCTGA TAGAAGATAC
-070 GGTGGCGATG TGTCGGGCAG AGTATGAGTG ATGATACACT GACCGCCTGA CGCACTAAGG AACAGCCAAA
0001 atgaccgaac ttaaaaacga tcgttatctg cgggcgctgc tgcgccagcc cgttgatgtc actccagtat
0071 ggatgatgcg ccaggcgggt cgctatctac cggaatataa agccacgcgc gcccaggcag gcgattttat
0141 gtcgctgtgc aaaaacgccg agctggcgtg cgaagtgact ttgcaaccgc tgcgtcgcta cccgctggat
0211 gcggcgatcc tcttttccga tatcctcacc gtgccggacg cgatggggtt agggctctat tttgaagccg
0281 gagaaggtcc gcgttttacc tcgccagtca cctgcaaagc tgacgtcgat aaactgccaa ttccggaccc
0351 ggaagatgaa ctgggttacg tgatgaacgc ggtgcgtacc attcgtcgcg aactgaaagg cgaagtgccg
0421 ctgattggtt tttccggcag cccgtggacg ctggcgacct acatggtgga aggcggcagc agcaaagcct
0491 tcaccgtgat caaaaaaatg atgtatgccg atccgcaggc gctgcacgct ctgctcgata aactggcgaa
0561 aagcgtcact ttgtatctga atgcgcagat taaagccggt gctcaggcag tgatgatttt cgacacctgg
0631 ggcggcgtgc ttaccgggcg cgattatcaa cagttctcgc tctattacat gcataaaatt gttgatggtt
0701 tactgcgtga aaacgacggt cgccgcgtac cggtcacgct gtttaccaaa ggcggcggac agtggctgga
0771 agccatggca gaaaccggtt gcgatgcgct gggcctcgac tggacaacgg acatcgccga tgcgcgccgc
0841 cgtgtgggca ataaagtcgc gttgcagggt aatatggatc cgtcgatgct gtacgcgccg cctgcccgca
0911 ttgaagaaga agtagcgact atacttgcag gtttcggtca cggcgaaggt catgtcttta accttggtca
0981 cggcattcat caggatgtgc cgccagaaca tgctggcgtg ttcgtggagg cagtgcatcg actgtctgaa
1051 cagtatcacc gctaaGGAGT GATTATGGAT CTCGCGTCAT TACGCGCTCA ACAAATCGAA CTGGCTTCTT
1121 CTGTGATCCG CGAGGATCGA CTCGATAAAG ATCCACCGGA TCTGA
|
